Longitudinal trajectories of intrinsic capacity and their association with quality of life and disability. Salinas-Rodríguez A, González-Bautista E, Rivera-Almaraz A, Manrique-Espinoza Betty. Associations between transitions of intrinsic capacity and frailty status, and 3-year disability. Association of intrinsic capacity with frailty, physical fitness and adverse health outcomes in community-dwelling older adults. Tay L, Tay EL, Mah SM, Latib A, Koh C, Ng YS. Implementation of the WHO integrated care for older people (ICOPE) programme in clinical practice: a prospective study. Tavassoli N, de Souto Barreto P, Berbon C, et al. Effects of incorporating multidomain interventions into integrated primary care on quality of life: a randomised controlled trial. Journal of cachexia, sarcopenia and muscle. Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster-randomized controlled trials. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Integrated care for older people (ICOPE): guidance for person-centred assessment and pathways in primary care. The World report on ageing and health: a policy framework for healthy ageing. Accessed.īeard JR, Officer A, De Carvalho IA, et al. Conclusion and ImplicationsĪ multidomain intervention in community-dwelling older adults improves cognitive decline and physical frailty, with its effectiveness influenced by baseline IC, highlighting the importance of personalized strategies for healthy aging. The poor vitality domain also had a significant modulating effect on the reduction of CHS frailty score after the 6- and 12-month intervention period (6 months: coefficient= −0.311, 95% CI: −0.554 ∼ −0.068 12 months: coefficient= −0.257, 95% CI: −0.513 ∼ −0.001). Significant improvements in MoCA scores were shown for participants with poorer baseline cognition (coefficient= 1.138, 95% CI: 0.080 ∼ 2.195) and vitality domains (coefficient= 1.651, 95% CI: 0.541 ∼ 2.760). To assess the associations between baseline poor capacity in each IC subdomain and MoCA/CHS frailty scores over follow-up, a 3-way interaction terms (time*intervention*each poorer IC subdomains) were added to GLMM models. After covariate adjustment using a generalized linear mixed model (GLMM), the multidomain intervention significantly prevented cognitive declines and physical frailty, particularly in those with IC impairment ≥ 3 subdomains (MoCA: coefficient: 1.909, 95% CI: 0.736 ∼ 3.083 CHS frailty scores: coefficient = −0.405, 95% CI: −0.715 ∼ −0.095). Of all participants (mean age:75.1☖.4 years, 68.6% female), about 90% participants had IC impairment at baseline (2.0☑.2 subdomains). Outcomes of interest were cognitive performance (MoCA scores) and physical frailty (CHS frailty score) over a follow-up period of 6 and 12 months. Measurementsīaseline IC was measured by 5 subdomains, including cognition (Montreal Cognitive Assessment, MoCA), sensory (visual and hearing impairment), vitality (handgrip strength or Mini-Nutritional Assessment-short form), psychological well-being (Geriatric Depression Scale-5), and locomotion (6m gait speed). InterventionĪ 12-month pragmatic multidomain intervention of exercise, cognitive training, nutritional counseling and chronic condition management. Setting and Participants: 1,054 community-dwelling older adults from 40 community-based clusters across Taiwan. DesignĪ cluster-randomized controlled trial. To examine roles of baseline IC and its subdomains on the efficacy of multidomain interventions in promoting healthy aging in older adults. Existing evidence suggests that multidomain interventions have the potential to enhance cognitive performance and yield positive effects on physical frailty. Impaired intrinsic capacity (IC), which affects approximately 90% of older adults, is associated with a significantly heightened risk of frailty and cognitive decline.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |